Patented Pro- acetyl hexapeptide-3 technology to achieve BOTOX effect.

Our lead product, Pro- acetyl hexapeptide-3，is built upon the highly acclaimed anti-wrinkle peptide, Acetyl hexapeptide-3, but went far beyond to transform its skin absorption method in a revolutionary way. Pro- acetyl hexapeptide-3 can deliver a single packaged solution to fight off wrinkles at the deepest level and rejuvenate facial skins. Pro- acetyl hexapeptide-3 represents the leading cosmeceutical technology to compete with BOTOX®, without injection and the associated cost.

Limitation of Existing Acetyl hexapeptide-3
Acetyl hexapeptide-3 is a unique peptide that can both reduce the degree of existing facial wrinkles and prevent wrinkles’ development. Its effectiveness has been tested and proven in lab environment. However, Acetyl hexapeptide-3 has very strong hypophilic (or “water-liking”) characteristics, therefore cannot penetrate the lipophilic (or “fat-liking”) skin barrier or stratum corneum. This has been a significant limitation of Acetyl hexapeptide-3, hence restraints the effectiveness of all existing Acetyl hexapeptide-3-based cosmeceuticals.

Pro- acetyl hexapeptide-3 Patented Structure
GRF scientists have developed the molecule, Pro- acetyl hexapeptide-3, to overcome the exact challenge Acetyl hexapeptide-3 has been facing for over ten years. The Pro- acetyl hexapeptide-3 molecule is a transformation of Acetyl hexapeptide-3 into a non-charged form, or Pro- acetyl hexapeptide-3. This transformation allows the Pro- acetyl hexapeptide-3 molecule to become lipophilic, while retaining all the essential functions of Acetyl hexapeptide-3. ro- acetyl hexapeptide-3 can penetrate the lipid-rich outer layers of skin and diffuse into the sub-layers of the epidermis, where cellular regeneration and keratinization occur.

GRF Biotech Patented Pro- acetyl hexapeptide-3 Structure

Pro- acetyl hexapeptide-3 Delivery Process
Pro- acetyl hexapeptide-3 can be absorbed into the skin unlike traditional Acetyl hexapeptide-3. A major challenge for all cosmeceuticals is the successful delivery of active ingredients across the skin barrier to really take effect at the substrata of the epidermis level. Pro- acetyl hexapeptide-3 enables Acetyl hexapeptide-3, which is known to have positive effects to fight wrinkles, to go beyond topical application and actually penetrate the epidermis. The lipophilic Pro- acetyl hexapeptide-3 molecules cross the skin barrier and slowly diffuse at an optimal rate into the sub-layers of the epidermis. As natural enzymes within the skin cleave on, Pro- acetyl hexapeptide-3 bio-converts back into the original Acetyl hexapeptide-3 active molecules, which enter the skin’s cells and aid in various biochemical reactions.




Once our patented Pro- acetyl hexapeptide-3 molecules reach the substrata of epidermis level and bio-converts back to Acetyl hexapeptide-3, the following two biochemical processes will happen:
The formation of SNARE complex and catecholamine release will be inhibited. These inhibitions confer anti-aging activity on Acetyl hexapeptide-3; they closely relate to the basic biochemical mechanisms of wrinkle formation.