The following scientific research papers by our scientists support the feasibility of Pro- acetyl hexapeptide-3 and the application of pro-drugs in general.

1. The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects. Wang Y, Wang M, Xiao XS, Pan P, Li P, Huo J. J Cosmet Laser Ther. 2013 Apr 22.

2. The anti-wrinkle efficacy of Argireline. Wang Y, Wang M, Xiao XS, Huo J, Zhang WD. J Cosmet Laser Ther. 2013 Aug;15(4):237-41. doi: 10.3109/14764172.2013.769273.

3. The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. Am J Clin Dermatol. 2013 Apr;14(2):147-53. doi: 10.1007/s40257-013-0009-9.

4. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Blanes-Mira C, Clemente J, Jodas G, Gil A, Fernández-Ballester G, Ponsati B, Gutierrez L, Pérez-Payá E, Ferrer-Montiel A. Int J Cosmet Sci. 2002 Oct;24(5):303-10. doi: 10.1046/j.1467-2494.2002.00153.x.

5. Preparation and stability of cosmetic formulations with an anti-aging peptide. Ruiz MA, Clares B, Morales ME, Cazalla S, Gallardo V. J Cosmet Sci. 2007 Mar-Apr;58(2):157-71.

6. Determination of Hexapeptide ALA-ASP-LEU-LYS-PRO-THR by MALDI MS, Anna Olejnik, Izabela Nowak, Krystian Eitner, Grzegorz Schroeder, Int J Pept Res Ther. 2013; 19: 217–224. Published online 2012 November 25. doi: 10.1007/s10989-012-9334-8

7. Identification of SNARE complex modulators that inhibit exocytosis from an alpha-helix-constrained combinatorial library. Clara Blanes-Mira, Maria T Pastor, Elvira Valera, Gregorio Fernández-Ballester, Jaime M Merino, Luis M Gutierrez, Enrique Perez-Payá, Antonio Ferrer-Montiel, Biochem J. 2003 October 1; 375(Pt 1): 159–166. doi: 10.1042/BJ20030509

8. Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers. Jain AK, Gund MG, Desai DC, Borhade N, Senthilkumar SP, Dhiman M, Mangu NK, Mali SV, Dubash NP, Halder S, Satyam A. Bioorg Chem. 2013 Aug;49:40-8. doi: 10.1016/j.bioorg.2013.06.007. Epub 2013 Jul 3.

9. Computer-assisted design for atenolol prodrugs for the use in aqueous formulations. Karaman R, Dajani K, Hallak H. J Mol Model. 2012 Apr;18(4):1523-40. doi: 10.1007/s00894-011-1180-7. Epub 2011 Jul 23.

10. Evaluation of ketone-oxime method for developing therapeutic on-demand cleavable immunoconjugates. Kumaresan PR, Luo J, Song A, Marik J, Lam KS. Bioconjug Chem. 2008 Jun;19(6):1313-8. doi: 10.1021/bc800024v. Epub 2008 May 22.

11. Development of magnetically separable immobilized lipase by using cellulose derivatives and their application in enantioselective esterification of ibuprofen. Lee G, Joo H, Kim J, Lee JH. J Microbiol Biotechnol. 2008 Mar;18(3):465-71.

12. The sensitivity of the cis/trans-isomerization of enalapril and enalaprilat to solvent conditions. Ledger R, Stellwagen E. J Pharm Pharmacol. 2005 Jul;57(7):845-50.

13. Synthesis of an esterase-sensitive cyclic prodrug of a model hexapeptide having enhanced membrane permeability and enzymatic stability using a 3-(2'-hydroxy-4',6'-dimethylphenyl)-3,3-dimethyl propionic Acid promoiety. Wang B, Gangwar S, Pauletti G, Siahaan T, Borchardt RT. Methods Mol Med. 1999;23:53-69. doi: 10.1385/0-89603-517-4:53.

14. Enzymatic activation of a doxorubicin-peptide prodrug by prostate-specific antigen. Denmeade SR, Nagy A, Gao J, Lilja H, Schally AV, Isaacs JT. Cancer Res. 1998 Jun 15;58(12):2537-40.

15. GPIIb/IIIa integrin antagonists with the new conformational restriction unit, trisubstituted beta-amino acid derivatives, and a substituted benzamidine structure. Hayashi Y, Katada J, Harada T, Tachiki A, Iijima K, Takiguchi Y, Muramatsu M, Miyazaki H, Asari T, Okazaki T, Sato Y, Yasuda E, Yano M, Uno I, Ojima I. J Med Chem. 1998 Jun 18;41(13):2345-60.

16. In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and itscarboxyl ester prodrug L-775,318. Roles of efflux and metabolism. Prueksaritanont T, DeLuna P, Gorham LM, Ma B, Cohn D, Pang J, Xu X, Leung K, Lin JH. Drug Metab Dispos. 1998 Jun;26(6):520-7.

17. Adenosine receptor prodrugs: towards kidney-selective dialkylxanthines. Barone S, Churchill PC, Jacobson KA. J Pharmacol Exp Ther. 1989 Jul;250(1):79-85.

18. Zhang Yanmei*；Dan Wei-Xing; Liu Jianqi; Tortorella D. Micky; Tu Zhengchao; Talley J. John*; Palladium-Catalyzed Synthesis of Trimethylsilyl Substituted Benzopyran Derivatives, The Open Organic Chemistry Journal, 2013, 7, 15-20

19. Chan Michael; Hayashi Tomoko; Mathewson Richard D.; Yao Shiyin; Gray Christine; Tawatao Romel I.; Kalenian Kevin; Zhang Yanmei; Hayashi Yuki; Lao Fitzgerald S.; Cottam Howard and Carson Dennis. Synthesis and Characterization of PEGylated Toll Like Receptor 7 Ligands, Bioconjugate Chemistry, 2011, 22, 445-454.

20. Zhang Yanmei; Saldanha Adrian; Elliott Greg; Tsygelny Igor; Carson Dennis and Wrasidlo Wolf. Synthesis of 5-(6-hydroxy- 7H-purine -8-ylthio)-2- (N-hydroxyformamido) pentanoic acid, Beilstein J. Org. Chem. 2010, 6, 742-747.

21. Hijazi Ahmed; Yeong Hui Yee; Zhang Yanmei; Herdtweck Eberhardt; Nuyken Oskar; Kühn Fritz E. Isobutene Polymerization Using [CuII(NCME)6]2+with Non Coordinating Anions as Catylysts, Macromol. Rapid Com. 2007, 28, 670-675.

22. Nuyken Oskar; Vierle Mario; Kühn Fritz E.; Zhang Yanmei. Solvent-Ligated Transition Metal Complexes as Initiators for the Polymerization of Isobutene, Macromolecular Symposia 2006, 236, 69-77.

23. Zhang Yanmei; Sun Wei; Freund C.; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Cationic copper(I) and silver(I) nitrile complexes with fluorinated weakly coordinating anions: metal-nitrile bond strength and its influence on the catalytic performance, Inorg. Chim. Acta. 2006, 359, 4723-4729.

24. Zhang Yanmei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Organonitrile Ligated Silver Complexes with Perfluorinated Weakly Coordinating Anions as Active Catalysts for Coupling Reactions, New. J. Chem. 2005, 29, 366-370.

25. Zhang Yanmei; Sun Wei; Santos Ana M.; Herdtweck Eberhardt; Mink Janos; Kühn Fritz E. Synthesis, characterization, and catalytic application of Copper(I) nitrile cations with perflurinated weakly coordinating anions, Catalysis Letters 2005, 101, 35-41.

26. Vierle Mario; Zhang Yanmei; Köhler Klaus; Haessner Carmen; Santos Ana M.; Herdtweck Eberhardt; Nuyken Oskar and Kühn Fritz E. Solvent Ligated Manganese (II) Complexes for the Homopolymerization of Isobutene and the Copolymerization of Isobutene and Isoprene, Chem. Eur. J. 2004, 10, 6323-6332.

27. Gago Sandra; Zhang Yanmei; Santos Ana M.; Köhler Klaus; Kühn Fritz E.; Fernandes Jose A.; Pillinger Martyn; Valente Anabela A.; Santos Teresa M.; Ribeiro-Claro Paulo; Goncalves Isabel S. Synthesis and characterization of a Manganese(II) acetonitrile complex supported on functionalized MCM-41, Microporous and Mesoporous Materials, 2004, 76, 131-136.

28. Kühn Fritz E.; Zuo Jing-Lin; Fabrizi de Biani Fabrizia; Santos Ana M.; Zhang Yanmei; Zhao Jin; Sandulache Angela and Herdtweck Eberhardt. 4-Ethynylpyridine as bridging moiety in mixed Ru/Re complexes, New J. Chem. 2004, 28, 43-51.

29. Vierle Mario; Zhang Yanmei; Herdtweck Eberhardt; Bohnenpoll Martin; Nuyken Oskar; Kuhn Fritz E. Highly reactive polyisobutene prepared with manganese(II) complexes as initiators, Angewandte Chemie, International Edition 2003, 42, 1307-1310.

30. Qing Feng-Ling; Ying Jiewen; Zhang Yanmei. A stereoselective synthesis of ethyl 9-cis-7,8-didehydro-19-trifluoromethylretinoate, Journal of Fluorine Chemistry 2000, 101, 31-33.

31. Qing Feng-Ling; Zhang Yanmei. Ethyl 3-Iodo-4,4,4-trifluoro-2(Z) -butenoate: regio- and stereospecific preparation and palladium-catalyzed reaction with terminal alkynes, Tetrahedron Letters 1997, 38, 6729-6732.